The absence of impairment of cliff avoidance reaction induced by subchronic methamphetamine treatment in inbred strains of mice

Sumiko Yoshida, Yohtaro Numachi, Hiroo Matsuoka, Mitsumoto Sato

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cliff avoidance reaction (CAR), an index of behavioral teratology in rodents, can be impaired by motor, arousal, or cognitive dysfunction. We formerly reported subchronic administration of methamphetamine (MAP) induced the CAR impairment, which might reflect MAP-induced cognitive dysfunction, in three strains of rats. In this study, the effects of subchronic MAP treatment on the behavioral sensitization in stereotypy (stereotypy sensitization) and CAR were examined in two inbred strains of male mice; C57BL/6J (C57) and DBA/2J(DBA). The animals received 4 mg/kg/day MAP intraperitoneally for 28 days. There were apparent strain differences in the development of stereotypy sensitization induced by chronic MAP; DBA mice developed stereotypy sensitization quickly, but C57 did not. Unlike rats, neither strains of mice showed the CAR impairment. These results suggest that chronic MAP (4 mg/kg) administration did not introduce any cognitive dysfunction measured by CAR in the two inbred mice, DBA and C57. The discrepancy between rats and mice is still unclear. It might relate to the species-selective effect of MAP on the CAR impairment. Further studies should to be required. (C) 2000 Tohoku University Medical Press.

Original languageEnglish
Pages (from-to)205-212
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume190
Issue number3
DOIs
Publication statusPublished - 2000 Mar

Keywords

  • Behavioral sensitization
  • Cliff avoidance reaction
  • Inbred strain
  • Methamphetamine
  • Mouse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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