Thallium-201 single-photon emission computed tomographic and proton magnetic resonance spectroscopic characteristics of intracranial ganglioglioma: Three technical case reports

Toshihiro Kumabe, Hiroaki Shimizu, Yukihiko Sonoda, Reizo Shirane

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

OBJECTIVE: The correlation between thallium-201 (201TI) uptake, semiquantitative choline-containing compound values measured by proton magnetic resonance spectroscopy (1H-MRS), and Ki-67 labeling indexes (LIs) was investigated in three gangliogliomas. METHODS: The early and delayed 201TI indexes were calculated as the ratio of tumor to normal brain tissue uptake by 201TI single-photon emission computed tomography. Single-voxel 1H-MRS was performed to measure the levels of metabolites in the tumors. Ki- 67 LI was measured in the surgical specimens. RESULTS: All three gangliogliomas showed very high 201TI uptake on both early and delayed images. 1H-MRS demonstrated malignancy based on the high choline peak relative to the creatine and N-acetylaspartate peaks. Ki-67 LI was less than 1% in two gangliogliomas and 3.5% in an anaplastic ganglioglioma. CONCLUSION: Both 201TI single-photon emission computed tomography and 1H-MRS indicated malignancy, whereas Ki-67 LI indicated low growth activity. 201TI single-photon emission computed tomography and 1H-MRS of ganglioglioma might be affected by metabolic characteristics other than growth activity.

Original languageEnglish
Pages (from-to)183-187
Number of pages5
JournalNeurosurgery
Volume45
Issue number1
DOIs
Publication statusPublished - 1999 Jul 1

Keywords

  • Ganglioglioma
  • Proton magnetic resonance spectroscopy
  • Thallium-201 single-photon emission computed tomography

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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