Tetrodotoxin in Asian newts (Salamandridae)

Mari Yotsu-Yamashita, Stefan W. Toennes, Dietrich Mebs

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Tetrodotoxin (TTX) and its analogues occur in a wide range of marine animals but also in terrestrial vertebrates such as frogs, toads and newts. Despite numerous studies on TTX in New World newts (Notophthalmus viridescens, Taricha spp.), few data only exist for Asian newts. Methanolic extracts of newts from China (Cynops orientalis, Pachytriton labiatus, Paramesotriton chinensis), Vietnam (Paramesotriton deloustali, P. guangxiensis), and Laos (Laotriton laoensis) were analyzed by liquid-chromatography-fluorescent detection (LC-FLD) and mass-spectrometry (LC-MS). In all species, variable amounts of TTX were detected, in most specimens also TTX-analogues like 6-epiTTX, in C. orientalis 11-oxoTTX, confirming the presence of these toxins in modern Asian newts.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalToxicon
Volume134
DOIs
Publication statusPublished - 2017 Aug

Keywords

  • 11-Oxotetrodotoxin
  • 6-Epitetrodotoxin
  • Asian newts
  • Cynops spp.
  • Laotriton laoensis
  • Pachytriton labiatus
  • Paramesotriton spp.
  • Tetrodotoxin

ASJC Scopus subject areas

  • Toxicology

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