Ternary complexes between DNA, polyamine, and cucurbituril: A modular approach to DNA-binding molecules

Hiroyuki Isobe, Naoki Tomita, Jae Wook Lee, Hee Joon Kim, Kimoon Kim, Eiichi Nakamura

    Research output: Contribution to journalArticlepeer-review

    77 Citations (Scopus)

    Abstract

    Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbit[6]uril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbit[6]uril).

    Original languageEnglish
    Pages (from-to)4257-4260
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume39
    Issue number23
    DOIs
    Publication statusPublished - 2000 Dec 4

    Keywords

    • DNA recognition
    • Intercalation
    • Rotaxanes
    • Supramolecular chemistry

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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