Terahertz irradiation effects on the morphology and dynamics of actin biopolymer

Hiromichi Hoshina, Shota Yamazaki, Masaaki Tsubouchi, Masahiko Harata

Research output: Contribution to journalArticlepeer-review

Abstract

Our recent experimental research on terahertz (THz) irradiation of actin filaments, which serve as representative biopolymer materials, is summarized in this review. We found that pulsed THz waves with energy density of ∼104 J cm2 (∼108 W cm2 at the peak) generate acoustic waves efficiently in the aqueous media. These acoustic waves propagated deeply into the water and demolished the actin filaments in living HeLa cells that were submerged into the cell culture medium. The results implied that THz pulsed irradiation affects the biomolecules in the tissues, even if these molecules are located a few millimeters away from the body surface. In contrast, irradiation using THz waves with lower peak power of the order of ∼W cm2 induces the elongation of the actin biopolymer without thermal or acoustic effects. The polymerization of actin molecules plays essential roles in cell motility, growth, differentiation and gene expression. Therefore, our results indicate that THz waves could be applicable to artificial manipulation of cellular functions.

Original languageEnglish
Article number034015
JournalJPhys Photonics
Volume3
Issue number3
DOIs
Publication statusPublished - 2021 Jul

Keywords

  • Actin
  • Biopolymer
  • Terahertz irradiation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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