Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiers

Teigo Asai, Yu Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang Rong Chang, Kouwa Yamashita, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

The concomitant addition of the histone deacetylase inhibitor and the DNA methyltransferase inhibitor to the culture medium of an entomopathogenic fungus, Isaria tenuipes, greatly enhanced its secondary metabolite production and led to the isolation of tenuipyrone (1), a novel polyketide with an unprecedented tetracyclic ring system bearing a spiroketal structural component, along with two known C 10-polyketides, cephalosporolide B (2), which is a plausible biosynthetic precursor of 1, and cephalosporolide F (3).

Original languageEnglish
Pages (from-to)513-515
Number of pages3
JournalOrganic letters
Volume14
Issue number2
DOIs
Publication statusPublished - 2012 Jan 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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