Temporo-parietal theta activity correlates with misery perfusion in arterial occlusive disease

Satoru Ohtomo, Nobukazu Nakasato, Hiroaki Shimizu, Shintarou Seki, Akitake Kanno, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: Temporo-parietal theta activity (TPTA), often detected in hemispheres with internal carotid (ICA) or middle cerebral artery (MCA) occlusive lesions, is more clearly separated from occipital alpha activity by magnetoencephalography (MEG) than electroencephalography. The present study investigated whether TPTA is correlated with misery perfusion, a surgically correctable type of hemodynamic impairment. Methods: Awake MEG was measured in 56 patients with ICA or MCA occlusive lesions. Regional cerebral blood flow (rCBF) and regional cerebrovascular reactivity (rCVR) to acetazolamide were measured in the MCA territory by xenon-133 single-photon emission computed tomography. MEG was repeated in 10 patients after vascular reconstruction surgery. Results: Fourteen patients showed TPTA in the lesion hemisphere (n = 13) or bilaterally (n = 1). The presence of TPTA was significantly correlated with both reduced rCBF and reduced rCVR (P = 0.0009). After surgery, TPTA disappeared in 7 of the 10 studied patients. Conclusions: The presence of TPTA suggests misery perfusion, which is characterized by reduced rCBF and reduced rCVR. Significance: MEG can detect the presence of reversible and surgically remediable cerebral ischemia before the development of complete infarction.

Original languageEnglish
Pages (from-to)1227-1234
Number of pages8
JournalClinical Neurophysiology
Volume120
Issue number7
DOIs
Publication statusPublished - 2009 Jul

Keywords

  • Brain infarction
  • Carotid stenosis
  • Cerebrovascular circulation
  • Magnetoencephalography
  • Theta activity

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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