Temporal Change in Brain Natriuretic Peptide After Radiotherapy for Thoracic Esophageal Cancer

Keiichi Jingu, Kenji Nemoto, Tomohiro Kaneta, Minako Oikawa, Yoshihiro Ogawa, Hisanori Ariga, Ken Takeda, Toru Sakayauchi, Keisuke Fujimoto, Kakutaro Narazaki, Yoshihiro Takai, Eiko Nakata, Hiroshi Fukuda, Shoki Takahashi, Shogo Yamada

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Purpose: To investigate the relationships of plasma levels of brain natriuretic peptide (BNP) with abnormal 18F-fluorodeoxyglucose (FDG) accumulation in the myocardium corresponding to irradiated fields and temporal changes in BNP, which is used as an index of heart remodeling, after radiotherapy for the mediastinum. Materials and Methods: Brain natriuretic peptide concentrations were measured before and after radiotherapy for thoracic esophageal cancer, and the change in BNP concentration after radiotherapy was investigated. Moreover, FDG accumulation in the myocardium was investigated in patients who had undergone FDG positron emission tomography less than 14 days before or after measurement of BNP concentration, and the Mann-Whitney U test was used to detect significant difference between BNP concentrations in patients with and without abnormal FDG accumulation corresponding to the irradiated field. Results: There was significant difference between the levels of BNP in patients without abnormal FDG accumulation in the irradiated myocardium and in patients with abnormal FDG accumulation (p < 0.001). The levels of BNP in the 9-24 months after radiotherapy group and in the >24 months after radiotherapy group were significantly higher than the levels in the before radiotherapy group, immediately after radiotherapy group, 1-2 months after radiotherapy group, and control group. Conclusions: The level of BNP was significantly increased more than 9 months after the start of radiotherapy and was significantly higher in patients who had high FDG accumulation corresponding to the irradiated field. The results of this study indicate that BNP concentration might be an early indicator of radiation-induced myocardial damage.

Original languageEnglish
Pages (from-to)1417-1423
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number5
Publication statusPublished - 2007 Dec 1


  • Brain natriuretic peptide
  • Esophageal cancer
  • MMP-3
  • Radiation-induced myocardial damage

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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