TY - GEN
T1 - Temporal and steady state acoustic field in a cell culture well
T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
AU - Choi, Min Joo
AU - Kang, Gwan Suk
AU - Kodama, Tetsuya
AU - Coleman, Andrew J.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - The present study was to understand the true power irradiated to the cell line cultured on a culture well, in relation to the nominal power from ultrasonic transducer, and to characterize the temporal variations of the acoustic pressure exerted on the cell. Numerical simulation was carried out for a typical culture well exposed to 1 MHz continuous ultrasound generated by a circular transducer contact underneath the well. The results showed that the ultrasonic pressure exposed to the cell layer in the well was 6.7 times larger than the nominal pressure of the ultrasonic transducer. The ultrasonic pressure in the transient period rose rapidly and was widely variable, and the temporal peak was even greater than that of the steady state period. This suggests that the cells undergo characteristically different ultrasonic exposure between the transient and the steady state period.
AB - The present study was to understand the true power irradiated to the cell line cultured on a culture well, in relation to the nominal power from ultrasonic transducer, and to characterize the temporal variations of the acoustic pressure exerted on the cell. Numerical simulation was carried out for a typical culture well exposed to 1 MHz continuous ultrasound generated by a circular transducer contact underneath the well. The results showed that the ultrasonic pressure exposed to the cell layer in the well was 6.7 times larger than the nominal pressure of the ultrasonic transducer. The ultrasonic pressure in the transient period rose rapidly and was widely variable, and the temporal peak was even greater than that of the steady state period. This suggests that the cells undergo characteristically different ultrasonic exposure between the transient and the steady state period.
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U2 - 10.1109/EMBC.2013.6609905
DO - 10.1109/EMBC.2013.6609905
M3 - Conference contribution
C2 - 24110092
AN - SCOPUS:84886526900
SN - 9781457702167
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1934
EP - 1935
BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Y2 - 3 July 2013 through 7 July 2013
ER -