Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain

Katsunori Tanaka; Sanae Shirotsuki; Takayuki Iwata; Chika Kageyama; Tsuyoshi Tahara; Satoshi Nozaki; Eric R.O. Siwu; Satoru Tamura; Shunsuke Douke; Nobutoshi Murakami; Hirotaka Onoe; Yasuyoshi Watanabe; Koichi Fukase

doi:10.1021/cb2003175

Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain

Katsunori Tanaka, Sanae Shirotsuki, Takayuki Iwata, Chika Kageyama, Tsuyoshi Tahara, Satoshi Nozaki, Eric R.O. Siwu, Satoru Tamura, Shunsuke Douke, Nobutoshi Murakami, Hirotaka Onoe, Yasuyoshi Watanabe, Koichi Fukase

SCI - Chemistry

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.

Original language	English
Pages (from-to)	637-645
Number of pages	9
Journal	ACS Chemical Biology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/cb2003175
Publication status	Published - 2012 Apr 20

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

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Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain. / Tanaka, Katsunori; Shirotsuki, Sanae; Iwata, Takayuki; Kageyama, Chika; Tahara, Tsuyoshi; Nozaki, Satoshi; Siwu, Eric R.O.; Tamura, Satoru; Douke, Shunsuke; Murakami, Nobutoshi; Onoe, Hirotaka; Watanabe, Yasuyoshi; Fukase, Koichi.

In: ACS Chemical Biology, Vol. 7, No. 4, 20.04.2012, p. 637-645.

Research output: Contribution to journal › Review article › peer-review

Tanaka, Katsunori ; Shirotsuki, Sanae ; Iwata, Takayuki ; Kageyama, Chika ; Tahara, Tsuyoshi ; Nozaki, Satoshi ; Siwu, Eric R.O. ; Tamura, Satoru ; Douke, Shunsuke ; Murakami, Nobutoshi ; Onoe, Hirotaka ; Watanabe, Yasuyoshi ; Fukase, Koichi. / Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain. In: ACS Chemical Biology. 2012 ; Vol. 7, No. 4. pp. 637-645.

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AU - Iwata, Takayuki

AU - Kageyama, Chika

AU - Tahara, Tsuyoshi

AU - Nozaki, Satoshi

AU - Siwu, Eric R.O.

AU - Tamura, Satoru

AU - Douke, Shunsuke

AU - Murakami, Nobutoshi

AU - Onoe, Hirotaka

AU - Watanabe, Yasuyoshi

AU - Fukase, Koichi

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AB - A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.

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Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain

Abstract

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