Abstract
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
Original language | English |
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Pages (from-to) | 637-645 |
Number of pages | 9 |
Journal | ACS Chemical Biology |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2012 Apr 20 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine