Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia

For intratissue hyperthermia, we have developed capsules contained temperature-sensitive amorphous metal flakes, which can also release anticancer agents. By applying an alternating magnetic field, the amorphous flakes continue to generate heat until the temperature reaches the Curie point. The maximum temperature of the capsule is controlled automatically within an accuracy of ±0.5 °C. In animal experiments, the capsules generate sufficient heat or intratissue hyperthermia with the enhanced release of the anticancer agent. By using the capsules, richly vascularized tumours, such as kidney or liver cancers, are considered to be treated by a multifunctional procedure consisting of embolization therapy, hyperthermia and chemotherapy.