TY - JOUR
T1 - Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans
AU - Kuhara, Atsushi
AU - Okumura, Masatoshi
AU - Kimata, Tsubasa
AU - Tanizawa, Yoshinori
AU - Takano, Ryo
AU - Kimura, Koutarou D.
AU - Inada, Hitoshi
AU - Matsumoto, Kunihiro
AU - Mori, Ikue
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/5/9
Y1 - 2008/5/9
N2 - Temperature is an unavoidable environmental cue that affects the metabolism and behavior of any creature on Earth, yet how animals perceive temperature is poorly understood. The nematode Caenorhabditis elegans "memorizes" temperatures, and this stored information modifies its subsequent migration along a temperature gradient. We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucleotide-binding protein (G protein)-mediated signaling, AWC was hyperresponsive to temperature, whereas the AIY interneuron (which is postsynaptic to AWC) was hyporesponsive to temperature. Thus, temperature sensation exhibits a robust influence on a neural circuit controlling a memory-regulated behavior.
AB - Temperature is an unavoidable environmental cue that affects the metabolism and behavior of any creature on Earth, yet how animals perceive temperature is poorly understood. The nematode Caenorhabditis elegans "memorizes" temperatures, and this stored information modifies its subsequent migration along a temperature gradient. We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucleotide-binding protein (G protein)-mediated signaling, AWC was hyperresponsive to temperature, whereas the AIY interneuron (which is postsynaptic to AWC) was hyporesponsive to temperature. Thus, temperature sensation exhibits a robust influence on a neural circuit controlling a memory-regulated behavior.
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U2 - 10.1126/science.1148922
DO - 10.1126/science.1148922
M3 - Article
C2 - 18403676
AN - SCOPUS:44049103544
VL - 320
SP - 803
EP - 807
JO - Science
JF - Science
SN - 0036-8075
IS - 5877
ER -