Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders

Nobuya Obana, Sho Takagi, Yoshitaka Kinouchi, Yoshihisa Tokita, Akihiro Sekikawa, Seiichi Takahashi, Nobuo Hiwatashi, Shinichi Oikawa, Tooru Shimosegawa

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective. Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods. We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results. The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion. Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalInternal Medicine
Volume42
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Keywords

  • Coronary diseases
  • Diabetes mellitus
  • Hypercholesterolemia
  • Telomere

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders'. Together they form a unique fingerprint.

  • Cite this

    Obana, N., Takagi, S., Kinouchi, Y., Tokita, Y., Sekikawa, A., Takahashi, S., Hiwatashi, N., Oikawa, S., & Shimosegawa, T. (2003). Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. Internal Medicine, 42(2), 150-153. https://doi.org/10.2169/internalmedicine.42.150