Telomere and telomerase: New markers for diagnosis of colorectal cancer

Y. Kinouchi, N. Hiwatashi, M. Chida, S. Kumagai, S. Takagi, K. Negoro, T. Toyota

Research output: Contribution to journalArticlepeer-review

Abstract

Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.

Original languageEnglish
Pages (from-to)1113-1117
Number of pages5
JournalJournal of the Japan Society of Colo-Proctology
Volume51
Issue number10
DOIs
Publication statusPublished - 1998

Keywords

  • Colorectal cancer
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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