Telomere and telomerase: New markers for diagnosis of colorectal cancer

Y. Kinouchi; N. Hiwatashi; M. Chida; S. Kumagai; S. Takagi; K. Negoro; T. Toyota

doi:10.3862/jcoloproctology.51.1113

Telomere and telomerase: New markers for diagnosis of colorectal cancer

Y. Kinouchi, N. Hiwatashi, M. Chida, S. Kumagai, S. Takagi, K. Negoro, T. Toyota

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Research output: Contribution to journal › Article › peer-review

Abstract

Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.

Original language	English
Pages (from-to)	1113-1117
Number of pages	5
Journal	Journal of the Japan Society of Colo-Proctology
Volume	51
Issue number	10
DOIs	https://doi.org/10.3862/jcoloproctology.51.1113
Publication status	Published - 1998

Keywords

Colorectal cancer
Telomerase
Telomere

ASJC Scopus subject areas

Surgery
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3862/jcoloproctology.51.1113

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title = "Telomere and telomerase: New markers for diagnosis of colorectal cancer",

abstract = "Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.",

keywords = "Colorectal cancer, Telomerase, Telomere",

author = "Y. Kinouchi and N. Hiwatashi and M. Chida and S. Kumagai and S. Takagi and K. Negoro and T. Toyota",

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TY - JOUR

T1 - Telomere and telomerase

T2 - New markers for diagnosis of colorectal cancer

AU - Kinouchi, Y.

AU - Hiwatashi, N.

AU - Chida, M.

AU - Kumagai, S.

AU - Takagi, S.

AU - Negoro, K.

AU - Toyota, T.

PY - 1998

Y1 - 1998

N2 - Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.

AB - Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.

KW - Colorectal cancer

KW - Telomerase

KW - Telomere

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Telomere and telomerase: New markers for diagnosis of colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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