Telomerase activity and telomerase reverse transcriptase (TERT) expression in ameloblastomas

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28 Citations (Scopus)

Abstract

Telomerase activity is believed to be crucial for cell immortalization and cancerization, and is proven to be induced by c-myc protein. Telomerase reverse transcriptase (TERT) has been recently identified as a catalytic subunit of telomerase, whose expression is closely correlated with telomerase activity. We estimated telomerase activity by the telomeric repeat amplification protocol (TRAP) assay and examined the immunohistochemical expression of TERT and c-myc protein in 21 ameloblastoma tissues. All ameloblastoma samples were positive for telomerase activity, and TERT expression was detected in the nuclei of neoplastic cells but not in those of stromal cells. Numerous peripheral columnar or cuboidal cells, sporadic central polyhedral cells and some granular cells in ameloblastomas reacted with anti-TERT antibody. These results suggest that telomerase activity is associated with the oncogenesis or proliferative potential of odontogenic epithelium. The expression of c-myc protein showed a similar distribution pattern to that of TERT, suggesting that c-myc protein might induce telomerase activity in ameloblastomas.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume30
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Ameloblastoma
  • Immunohistochemistry
  • Telemorase reverse transcriptase (TERT)
  • Telomerase activity
  • Telomeric repeat amplification protocol (TRAP) assay
  • c-myc protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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