Abstract
By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.
Original language | English |
---|---|
Pages (from-to) | 1598-1600 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2010 Mar 1 |
Externally published | Yes |
Keywords
- Envelope protein E1, E2
- HCV
- Invasion inhibitor
- Rosa rugosa Thunb.
- Tellimagrandin I
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry