Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

Satoru Tamura; Gang Ming Yang; Natsuko Yasueda; Yoshiharu Matsuura; Yasumasa Komoda; Nobutoshi Murakami

doi:10.1016/j.bmcl.2010.01.084

Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

Satoru Tamura, Gang Ming Yang, Natsuko Yasueda, Yoshiharu Matsuura, Yasumasa Komoda, Nobutoshi Murakami

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.

Original language	English
Pages (from-to)	1598-1600
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2010.01.084
Publication status	Published - 2010 Mar 1

Keywords

Envelope protein E1, E2
HCV
Invasion inhibitor
Rosa rugosa Thunb.
Tellimagrandin I

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos",

abstract = "By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.",

keywords = "Envelope protein E1, E2, HCV, Invasion inhibitor, Rosa rugosa Thunb., Tellimagrandin I",

author = "Satoru Tamura and Yang, {Gang Ming} and Natsuko Yasueda and Yoshiharu Matsuura and Yasumasa Komoda and Nobutoshi Murakami",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Culture and Sports, and Research funds from San-Ei Gen F. F. I. Inc. The authors are grateful to the Kampou Science Foundation for financial support.",

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doi = "10.1016/j.bmcl.2010.01.084",

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T1 - Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

AU - Tamura, Satoru

AU - Yang, Gang Ming

AU - Yasueda, Natsuko

AU - Matsuura, Yoshiharu

AU - Komoda, Yasumasa

AU - Murakami, Nobutoshi

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Culture and Sports, and Research funds from San-Ei Gen F. F. I. Inc. The authors are grateful to the Kampou Science Foundation for financial support.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.

AB - By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.

KW - Envelope protein E1, E2

KW - HCV

KW - Invasion inhibitor

KW - Rosa rugosa Thunb.

KW - Tellimagrandin I

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Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

Abstract

Keywords

ASJC Scopus subject areas

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