Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

Satoru Tamura, Gang Ming Yang, Natsuko Yasueda, Yoshiharu Matsuura, Yasumasa Komoda, Nobutoshi Murakami

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.

Original languageEnglish
Pages (from-to)1598-1600
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number5
DOIs
Publication statusPublished - 2010 Mar 1

Keywords

  • Envelope protein E1, E2
  • HCV
  • Invasion inhibitor
  • Rosa rugosa Thunb.
  • Tellimagrandin I

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Tamura, S., Yang, G. M., Yasueda, N., Matsuura, Y., Komoda, Y., & Murakami, N. (2010). Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos. Bioorganic and Medicinal Chemistry Letters, 20(5), 1598-1600. https://doi.org/10.1016/j.bmcl.2010.01.084