TY - JOUR
T1 - Tebuconazole derivatives are potent inhibitors of strigolactone biosynthesis
AU - Ito, Shinsaku
AU - Umehara, Mikihisa
AU - Hanada, Atsushi
AU - Yamaguchi, Shinjiro
AU - Asami, Tadao
PY - 2013/10/29
Y1 - 2013/10/29
N2 - To find strigolactone (SL) biosynthesis inhibitors, we screened the azolecontaining chemicals that reduce the level of 2′-epi-5-deoxystrigol (epi-5DS) in rice. As a result of the screening, tebuconazole, a known fungicide targeting ergosterol biosynthesis, was selected as a potent SL biosynthesis inhibitor. A structure-activity relationship study of tebuconazole was carried out to discover more potent SL biosynthesis inhibitors. By evaluating the inhibitory activity on epi-5DS biosynthesis, we found that 2-(2-chlorophenyl)-4-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (4b) and 4-(4-chlorophenyl)-2-(4-phenoxyphenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (4e) showed potent ability to reduce epi-5DS biosynthesis.
AB - To find strigolactone (SL) biosynthesis inhibitors, we screened the azolecontaining chemicals that reduce the level of 2′-epi-5-deoxystrigol (epi-5DS) in rice. As a result of the screening, tebuconazole, a known fungicide targeting ergosterol biosynthesis, was selected as a potent SL biosynthesis inhibitor. A structure-activity relationship study of tebuconazole was carried out to discover more potent SL biosynthesis inhibitors. By evaluating the inhibitory activity on epi-5DS biosynthesis, we found that 2-(2-chlorophenyl)-4-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (4b) and 4-(4-chlorophenyl)-2-(4-phenoxyphenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (4e) showed potent ability to reduce epi-5DS biosynthesis.
KW - Biosynthesis inhibitor
KW - P450
KW - Strigolactone
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U2 - 10.1584/jpestics.D13-011
DO - 10.1584/jpestics.D13-011
M3 - Article
AN - SCOPUS:84886279153
VL - 38
SP - 147
EP - 151
JO - Journal of Pesticide Sciences
JF - Journal of Pesticide Sciences
SN - 1348-589X
IS - 3
ER -