Tebuconazole derivatives are potent inhibitors of strigolactone biosynthesis

Shinsaku Ito, Mikihisa Umehara, Atsushi Hanada, Shinjiro Yamaguchi, Tadao Asami

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    To find strigolactone (SL) biosynthesis inhibitors, we screened the azolecontaining chemicals that reduce the level of 2′-epi-5-deoxystrigol (epi-5DS) in rice. As a result of the screening, tebuconazole, a known fungicide targeting ergosterol biosynthesis, was selected as a potent SL biosynthesis inhibitor. A structure-activity relationship study of tebuconazole was carried out to discover more potent SL biosynthesis inhibitors. By evaluating the inhibitory activity on epi-5DS biosynthesis, we found that 2-(2-chlorophenyl)-4-(4-chlorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (4b) and 4-(4-chlorophenyl)-2-(4-phenoxyphenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (4e) showed potent ability to reduce epi-5DS biosynthesis.

    Original languageEnglish
    Pages (from-to)147-151
    Number of pages5
    JournalJournal of Pesticide Science
    Issue number3
    Publication statusPublished - 2013 Oct 29


    • Biosynthesis inhibitor
    • P450
    • Strigolactone

    ASJC Scopus subject areas

    • Insect Science
    • Health, Toxicology and Mutagenesis


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