Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats

Ikuo Ikeda, Koichi Tsuda, Yuko Suzuki, Makoto Kobayashi, Tomonori Unno, Hiroko Tomoyori, Hitomi Goto, Yayoi Kawata, Katsumi Imaizumi, Ayumu Nozawa, Takami Kakuda

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)

Abstract

Tea catechins, (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), have been shown to be epimerized to (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG), and (-)-gallocatechin gallate (GCG), respectively, during heat treatment. In this study, we examined the effect of tea catechins rich in ECG and EGCG and heat-treated tea catechins rich in CG and GCG on postprandial hypertriacylglycerolemia in rats. Both tea catechins and heat-treated tea catechins suppressed postprandial hypertriacylglycerolemia. Lymphatic recovery of 14C-trioleoylglycerol in rats cannulated in the thoracic duct was delayed by the administration of tea catechins and heat-treated tea catechins. Tea catechins and heat-treated tea catechins had the same effect on all variables tested. These catechin preparations dose-dependently inhibited the activity of pancreatic lipase in vitro. When purified catechins were used, only those with a galloyl moiety inhibited the activity of pancreatic lipase. These results suggest that catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by slowing down triacylglycerol absorption through the inhibition of pancreatic lipase. Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Nutrition
Volume135
Issue number2
DOIs
Publication statusPublished - 2005 Feb

Keywords

  • Catechins
  • Pancreatic lipase
  • Postprandial hypertriacylglycerolemia
  • Rats
  • Tea

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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