Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase

Masaki Saito, Ayano Chiba, Takeya Sato, Takahiro Moriya, Jun Sukegawa, Norimichi Nakahata

Research output: Contribution to journalArticlepeer-review


Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalJournal of Pharmacological Sciences
Issue number1
Publication statusPublished - 2021 Jan
Externally publishedYes


  • Adenylyl cyclase
  • Cytoplasmic dynein light chain Tctex-1
  • Parathyroid hormone receptor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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