Taurocholate-induced gastric damage in rats with obstructive jaundice

T. Matsuo, Iwao Sasaki, Y. Kamiyama, H. Naitoh, Y. Funayama, M. Takahashi, K. Fukushima, S. Matsuno

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the severity of taurocholate-induced gastric mucosal damage in rats with obstructive jaundice. Oral administration of 100 mM taurocholate induced severer gastric mucosal damage in rats with jaundice than in intact rats. Pretreatment with 5 mM taurocholate significantly protected the gastric mucosa against 100 mM taurocholate-induced damage, suggesting adaptive cytoprotection in rats with jaundice. The reductions in the gastric mucosal potential difference and hexosamine contents in the gastric mucosa in response to 100 mM taurocholate were significantly attenuated by prior administration of 5 mM taurocholate in both intact rats and rats with jaundice.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalScandinavian journal of gastroenterology
Volume24
Issue numberS162
DOIs
Publication statusPublished - 1989 Jan 1

Keywords

  • Adaptive cytoprotection
  • Hexosamine content
  • Obstructive jaundice
  • Potential difference
  • Taurocholate

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Matsuo, T., Sasaki, I., Kamiyama, Y., Naitoh, H., Funayama, Y., Takahashi, M., Fukushima, K., & Matsuno, S. (1989). Taurocholate-induced gastric damage in rats with obstructive jaundice. Scandinavian journal of gastroenterology, 24(S162), 83-86. https://doi.org/10.3109/00365528909091131