Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions

Victor L. Villemagne, Nobuyuki Okamura

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. The cross-sectional and longitudinal assessment of the temporal and spatial patterns of tau deposition in the brain will allow a better understanding of the role tau plays in ageing as well as its relationship with cognition, genotype, and neurodegeneration. It is likely that selective tau imaging could be used as a diagnostic and prognostic biomarker of disease progression, as well as a surrogate marker for monitoring of efficacy and patient recruitment for disease-specific therapeutic trials.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume36
DOIs
Publication statusPublished - 2016 Feb 1

ASJC Scopus subject areas

  • Neuroscience(all)

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