Taspase 1: A protease with many biological surprises

Hidetaka Niizuma, Emily H. Cheng, James J. Hsieh

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.

Original languageEnglish
Article numbere999513
JournalMolecular and Cellular Oncology
Volume2
Issue number4
DOIs
Publication statusPublished - 2015 Oct 2

Keywords

  • CDK inhibitor
  • MLL
  • TFIIA
  • Taspase 1
  • cyclin

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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