Targeting selective autophagy by AUTAC degraders

Research output: Contribution to journalComment/debate

Abstract

Targeted degradation is a promising new modality in drug discovery that makes it possible to reduce intracellular protein levels with small molecules. It is a complementary approach to the conventional protein knockdown typically used in laboratories and may offer a way to approach the currently undruggable human proteome. Recently, the first autophagy-mediated degraders, called AUTACs, were developed based on observations in a xenophagy study.

Original languageEnglish
Pages (from-to)765-766
Number of pages2
JournalAutophagy
Volume16
Issue number4
DOIs
Publication statusPublished - 2020 Apr 2

Keywords

  • AUTAC
  • PROTAC
  • drug discovery
  • guanylation
  • mitophagy
  • targeted degradation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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