Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection

Md Shenuarin Bhuiyan, Norifumi Shioda, Koji Fukunaga

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Background: Akt is an important signaling molecule that modulates many cellular processes such as cell growth, survival and metabolism. Akt activation has been proposed as a potential strategy for increasing cardiomyocyte survival following ischemia. Objectives: Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia/reperfusion-induced injury along with cardiac functional recovery. Like other vanadium compounds, we documented bis(1-oxy-2-pyridinethiolato) oxovanadium (IV) as a potent cytoprotective agent on myocardial infarction and elicited cardiac functional recovery through activation of Akt signaling pathway. Results/conclusion: The ability of vanadium compounds to activate Akt signaling pathways are responsible for their ability to modulate cardiovascular functions and is probably beneficial as a cardioprotective drug in subjects undergoing reperfusion therapy following myocardial infarction.

Original languageEnglish
Pages (from-to)1217-1227
Number of pages11
JournalExpert Opinion on Therapeutic Targets
Volume12
Issue number10
DOIs
Publication statusPublished - 2008 Oct 1

Keywords

  • Bim
  • Fas ligand
  • Forkhead transcription factor
  • Myocardial ischemia/reperfusion
  • Protein kinase B/Akt
  • VO(OPT)

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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