Targeting nitrosative stress for neurovascular protection: New implications in brain diseases

Rong Rong Tao, Yue Long Ji, Ying Mei Lu, Koji Fukunaga, Feng Han

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Nitric oxide/peroxynitrite signaling is associated with manifold neurovascular pathogenic cascades that lead to neurodegenerative diseases, including ischemic stroke, Alzheimer's disease, and vascular dementia. Considerable evidence suggests that reactive nitrogen species as mediators of nitrosative stress could damage biomolecules and subsequently facilitate the breakdown of the highly-structured cellular machinery. Herein, we focus on nitrosative stress signaling, which is intimately associated with endothelial cell injury and blood-brain barrier damage in stroke and neurodegenerative diseases. Unraveling the detrimental role of nitrosative stress signaling in initiating and driving neurovascular pathogenesis may lead to the development of novel vasoprotective strategies via restorative therapies for brain diseases.

Original languageEnglish
Pages (from-to)272-284
Number of pages13
JournalCurrent Drug Targets
Volume13
Issue number2
DOIs
Publication statusPublished - 2012 Feb 1

Keywords

  • Blood-brain barrier
  • Cerebral ischemia
  • Endothelium
  • Nitrosative stress
  • Peroxynitrite
  • Vasoprotection

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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