Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progression

Yifeng Lei, Yoh Hamada, Jun Li, Liman Cong, Nuoxin Wang, Ying Li, Wenfu Zheng, Xingyu Jiang

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Pancreatic cancer is a lethal malignancy whose progression is highly dependent on the nervous microenvironment. This study develops neural drug-loaded ferritin nanoparticles (Ft NPs) to regulate the nervous microenvironment, in order to control the pancreatic cancer progression. The drug-loaded Ft NPs can target pancreatic tumors via passive targeting of EPR effects of tumors and active targeting via transferrin receptor 1 (TfR1) binding on cancer cells, with a triggered drug release in acidic tumor environment. Two drugs, one activates neural activity (carbachol), the other impairs neural activity (atropine), are encapsulated into the Ft NPs to form two kinds of nano drugs, Nano-Cab NPs and Nano-Ato NPs, respectively. The activation of the nervous microenvironment by Nano-Cab NPs significantly promotes the pancreatic tumor progression, whereas the blockage of neural niche by Nano-Ato NPs remarkably impairs the neurogenesis in tumors and the progression of pancreatic cancer. The Ft-based nanoparticles thus comprise an effective and safe route of delivery of neural drugs for novel anti-cancer therapy.

Original languageEnglish
Pages (from-to)131-142
Number of pages12
JournalJournal of Controlled Release
Volume232
DOIs
Publication statusPublished - 2016 Jun 28

Keywords

  • Drug delivery
  • Ferritin nanoparticles
  • Nervous microenvironment
  • Pancreatic cancer

ASJC Scopus subject areas

  • Pharmaceutical Science

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