Targeted drug delivery system for oral cancer therapy using sonoporation

Hironobu Maeda, Kazuhiro Tominaga, Kenjiro Iwanaga, Fuminori Nagao, Manabu Habu, Toshiyuki Tsujisawa, Yuji Seta, Kuniaki Toyoshima, Jin Ichi Fukuda, Tatsuji Nishihara

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Ultrasound-mediated destruction of microbubbles has been proposed as an innovative non-invasive drug delivery system for cancer therapy. We developed a specific drug delivery system for squamous cell carcinoma that uses sonoporation with the anti-epidermal growth factor receptor (EGFR) antibody. Administration of a low dose of bleomycin (BLM) by sonoporation with the anti-EGFR antibody produced a marked growth inhibition of Ca9-22 cells in vitro. In addition, scanning electron microscopic analysis revealed apparent surface deformation of Ca9-22 cells treated with sonoporation in the presence of the antibody. Interestingly, the population of apoptotic cells was remarkably increased when a low dose of BLM was delivered using sonoporation with the Fab fragment of the anti-EGFR antibody. These findings indicate that sonoporation with the Fab fragment makes it possible to administer drugs into cells more efficiently and specifically, suggesting a novel application for chemotherapy and gene therapy treatments for oral squamous cell carcinoma. J Oral Pathol Med (2009) 38: 572-579 2009 John Wiley & Sons A/S.

Original languageEnglish
Pages (from-to)572-579
Number of pages8
JournalJournal of Oral Pathology and Medicine
Issue number7
Publication statusPublished - 2009 Aug 1
Externally publishedYes


  • Anti-epidermal growth factor receptor antibody
  • Apoptosis
  • Sonoporation
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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