Tag-reporter and resin capture - Release strategy in oligosaccharide synthesis

Yukishige Ito, Shino Manabe

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Low molecular weight poly(ethylene glycol) (LWPEG) has been found to be useful as a "tag" in oligosaccharide synthesis due to its high polarity. Realtime reaction monitoring was achieved by use of MALDI-TOF MS in the glycosylation reactions and color tests in the deprotection of the chloroacetyl group. Further, a cysteine-supported insoluble resin enables the purification of the chloroacetyl-bound compounds on soluble PEG.

Original languageEnglish
Pages (from-to)3076-3084
Number of pages9
JournalChemistry - A European Journal
Volume8
Issue number14
DOIs
Publication statusPublished - 2002 Jul 15
Externally publishedYes

Keywords

  • Capture-release purification
  • Oligosaccharides
  • Polymer-supported synthesis
  • Real-time monitoring
  • Synthesis design

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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