Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice

Akiyo Sekimoto, Kayo Tanaka, Yamato Hashizume, Emiko Sato, Hiroshi Sato, Tomoaki Ikeda, Nobuyuki Takahashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: – Tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, alleviates preeclampsia (PE), and decreases the fetal and infant deaths associated with fetal growth restriction (FGR) in phase II clinical trial. Recently, we demonstrated that tadalafil alleviates FGR and hypertension in the dams with PE induced by L-NAME. Objective: –The aim of present study was to clarify the effect of tadalafil in another mouse model of PE, murine reduced uterine perfusion pressure (RUPP) model we have recently developed. Methods: –At 14.5 dpc we performed RUPP operation in mice to induce PE, administered the animals with tadalafil or vehicle in the drinking water daily from 15.5 dpc, and sacrificed them at 18.5 dpc for analyses. Results: –Tadalafil improved maternal hypertension and glomerular endotheliosis in RUPP mice. Moreover, tadalafil prolonged pregnancy period, and improved survival and growth of the embryos. RUPP increased content of sFlt-1 protein in the placenta, and tadalafil corrected it back to control levels. Conclusion: – Tadalafil alleviates PE-like phenotype and FGR in RUPP murine model. RUPP model could help understand the mechanism of how tadalafil works on PE and FGR.

Original languageEnglish
Pages (from-to)769-774
Number of pages6
JournalBiochemical and biophysical research communications
Volume521
Issue number3
DOIs
Publication statusPublished - 2020 Jan 15

Keywords

  • Fetal growth restriction
  • Phosphodiesterase 5 inhibitor
  • Preeclampsia
  • Reduced uterine perfusion pressure model
  • Tadalafil

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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