T cell development in mice lacking all T cell receptor ζ family members (ζ, η, and FcεRIγ)

Elizabeth W. Shores, Masao Ono, Tsutomo Kawabe, Connie L. Sommers, Tom Tran, Kin Lui, Mark C. Udey, Jeffrey Ravetch, Paul E. Love

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The ζ family includes ζ, η, and FcεRIγ (Fcγ). Dimers of the ζ family proteins function as signal transducing subunits of the T cell antigen receptor (TCR), the pre-TCR, and a subset of Fc receptors. In mice lacking ζ/η chains, T cell development is impaired, yet low numbers of CD4+ and CD8+ T cells develop. This finding suggests either that pre-TCR and TCR complexes lacking a ζ family dimer can promote T cell maturation, or that in the absence of ζ/η, Fcγ serves as a subunit in TCR complexes. To elucidate the role of ζ family dimers in T cell development, we generated mice lacking expression of all of these proteins and compared their phenotype to mice lacking only ζ/η or Fcγ. The data reveal that surface complexes that are expressed in the absence of ζ family dimers are capable of transducing signals required for α/β-T cell development. Strikingly, T cells generated in both ζ/η(-/-) and ζ/η(-/-)- Fcγ(-/-) mice exhibit a memory phenotype and elaborate interferon γ. Finally, examination of different T cell populations reveals that ζ/η and Fcγ have distinct expression patterns that correlate with their thymus dependency. A possible function for the differential expression of ζ family proteins may be to impart distinctive signaling properties to TCR complexes expressed on specific T cell populations.

Original languageEnglish
Pages (from-to)1093-1101
Number of pages9
JournalJournal of Experimental Medicine
Volume187
Issue number7
DOIs
Publication statusPublished - 1998 Apr 6

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Shores, E. W., Ono, M., Kawabe, T., Sommers, C. L., Tran, T., Lui, K., Udey, M. C., Ravetch, J., & Love, P. E. (1998). T cell development in mice lacking all T cell receptor ζ family members (ζ, η, and FcεRIγ). Journal of Experimental Medicine, 187(7), 1093-1101. https://doi.org/10.1084/jem.187.7.1093