Systems biology approaches in breast cancer studies

Zhiwei Wang, Shavali Shaik, Hiroyuki Inuzuka, Wenyi Wei

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Breast cancer is the second most common malignancy for women. Currently, only several prognostic and predictive factors are used clinically for managing breast cancer patients. Recently, systems biology approaches based on high-throughput technologies such as DNA microarrays, mass spectrometry-based proteomics and metabolomics have began to be used to investigate the expression of a wide range of genes and proteins in the dissected breast tumors. Moreover, these expression signatures have been found to provide potential and independent prognostic information in patients diagnosed with breast cancer. Furthermore, these molecular signatures could not only help to identify new therapeutic targets, but also allow physicians to design more effective and targeted therapeutic strategies for achieving better treatment outcomes of breast cancer patients.

Original languageEnglish
Title of host publicationBreast Cancer Metastasis and Drug Resistance
Subtitle of host publicationProgress and Prospects
PublisherSpringer New York
Number of pages12
ISBN (Electronic)9781461456476
ISBN (Print)1461456460, 9781461456469
Publication statusPublished - 2013 Aug 1
Externally publishedYes


  • DNA microarray
  • Dissociable antibody microarray (DAMA)
  • Estrogen receptor (ER)
  • Factors for increased breast cancer incidence
  • Gene annotation tool to help explain relationships (GATHER)
  • Human epidermal growth factor receptor 2 (Her2)
  • Mass spectrometry-based proteomics
  • Metabolomics
  • MicroRNA microarray
  • Progesterone receptor (PR)
  • Systems biology
  • Systems biology approaches
  • Tissue microarray
  • Triple-negative breast cancers (TNBC)
  • cDNA-mediated annealing selection extension and ligation (DASL)

ASJC Scopus subject areas

  • Medicine(all)


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