Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin

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5 Citations (Scopus)

Abstract

IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCase Reports in Dermatology
Volume4
Issue number2
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

Keywords

  • Activated antigen-presenting cells
  • IL-27
  • Type 1 helper T cells

ASJC Scopus subject areas

  • Dermatology

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