Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues

Norihiro Shimada, Takashi Suzuki, Satoshi Inoue, Katsuaki Kato, Akira Imatani, Hitoshi Sekine, Syuichi Ohara, Tooru Shimosegawa, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Estrogen-responsive finger protein (Efp), a target gene product of estrogen receptor (ER), is considered essential for estrogen-dependent cell proliferation. The biological significance of Efp remains unclear in human tissues, and therefore, we examined systemic distribution of Efp in human adult and fetal tissues using RT-PCR and immunohistochemistry. Efp mRNA expression was marked in the placenta and uterus, high in the thyroid gland, aorta, and spleen in adult, and relatively low in other human adult and fetal tissues examined in this study. Efp immunoreactivity was detected in epithelium of various adult tissues, and was also detected in cytotrophoblasts of the placenta and splenic macrophages. Efp immunolocalization in human fetus was generally similar as that in adult. These Efp-positive cells were previously reported to be associated with ERα and/or ERβ expression. Therefore, these results indicate that Efp is widely expressed and may play important roles in various human tissues possibly through ERs.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume218
Issue number1-2
DOIs
Publication statusPublished - 2004 Apr 15

Keywords

  • Distribution
  • Estrogen-responsive finger protein (Efp)
  • Human tissues
  • Immunohistochemistry
  • Reverse transcriptase-polymerase chain reaction (RT-PCR)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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