Systematic analysis of embryonic expression profiles of zinc finger genes in Ciona intestinalis

Kyoko Miwata, Takuto Chiba, Reiko Horii, Lixy Yamada, Atsushi Kubo, Daisuke Miyamura, Nori Satoh, Yutaka Satou

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

The recent decoding of a number of animal genomes has provided unprecedented information regarding evolution and gene structures, but this information must be supplemented with precise gene annotations and the temporal and spatial expression patterns of individual genes. In the present study, we systematically identified and characterized 566 zinc finger genes in the genome of Ciona intestinalis, an emerging model system for genome-wide studies of development and evolution. Of these genes, 356 genes encoded a potential transcription factor based on putative nucleic acid binding activity or domains of unknown function. We further examined the expression patterns of 225 genes during embryogenesis, and, when considered with a previous study [Imai, K.S., Hino, K., Yagi, K., Satoh, N., Satou, Y., 2004. Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks. Development 131, 4047-4058], we have characterized the developmental expression patterns of nearly 85% of the potential zinc finger-containing transcription factors. Overall, zinc finger genes are preferentially maternally expressed with little larval expression during development. The present study provides a valuable reference for genome-wide studies in this species and for future studies wishing to examine zinc finger gene expression patterns in other animals.

Original languageEnglish
Pages (from-to)546-554
Number of pages9
JournalDevelopmental Biology
Volume292
Issue number2
DOIs
Publication statusPublished - 2006 Apr 15

Keywords

  • Ascidian
  • Ciona intestinalis
  • Expression profile
  • Zinc finger

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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