Synthetic studies toward penitrem E: Enantiocontrolled construction of B-E rings

Yu Yoshii, Takanori Otsu, Norihiko Hosokawa, Kiyosei Takasu, Kentaro Okano, Hidetoshi Tokuyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Enantiocontrolled construction of B-E rings of penitrem E was accomplished from 4-iodoindole in 13 steps with an overall yield of 1.7%. Diastereoselective Tf2NH-catalyzed (2+2)-cycloaddition between silyl enol ether and methyl acrylate furnished a tetracyclic product possessing the characteristic cyclobutane ring bearing a hydroxyl group. This journal is

Original languageEnglish
Pages (from-to)1070-1073
Number of pages4
JournalChemical Communications
Volume51
Issue number6
DOIs
Publication statusPublished - 2015 Jan 21

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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