Synthetic studies on pseudolaric acid B: Construction of the trans-fused [5–7] ring system via Dieckmann condensation

Naoki Mori, Chiaki Mase, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pseudolaric acids A (1) and B (2) are diterpene acids isolated from the root bark of Pseudolarix kaempferi as the main biologically active constituents of tujinpi, a traditional Chinese medicinal herb. Studies toward the total synthesis of 2 are described. The unusual trans-fused [5–7] ring system in the core structure of 2 was successfully synthesized via Dieckmann condensation.

Original languageEnglish
Pages (from-to)2600-2603
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number26
DOIs
Publication statusPublished - 2018 Jun 27
Externally publishedYes

Keywords

  • Dieckmann condensation
  • Diterpenes
  • Peudolaric acids
  • Trans-fused [5–7] ring system

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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