Abstract
A synthesis of the core framework of presporolide, which possesses both a strained bicyclo[7.3.0]dodecadiyne moiety and a distinctive macrolactone structure, is reported. This synthesis features: (i) a Cu-mediated O-arylation of a hindered tertiary alcohol using triarylbismuth reagent; (ii) stereoselective construction of the strained nine-membered diyne ring; and (iii) atroposelective formation of the macrolactone.
Original language | English |
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Pages (from-to) | 276-279 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2018 Jan 5 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry