Synthetic studies on plakinidines

Takahito Satoh, Touma Adachi, Kentaro Okano, Juri Sakata, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Synthetic studies on plakinidines are described. As a model study for the construction of the dihydropyridone ring at the final stage of the synthesis, we investigated a Meyer–Schuster rearrangement/aza-Michael cyclization cascade. The B,C,D,E ring system possessing a pyrrolo[2,3,4-kl]acridine structure was constructed via a benzyne-mediated cyclization/functionalization sequence that involved the formation of a β,β-diarylethylamine derivative and a palladium-catalyzed double aryl amination of a 3-arylindoline intermediate as key processes.

Original languageEnglish
Pages (from-to)310-323
Number of pages14
JournalHeterocycles
Volume99
Issue number1
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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