Synthetic studies on goniodomin A: Convergent assembly of the C15-C36 segment via palladium-catalyzed organostannane-thioester coupling

Tomoyuki Saito, Haruhiko Fuwa, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    A stereocontrolled convergent synthesis of the C15-C36 segment of goniodomin A, a potent anti-angiogenic marine polyether macrolide, has been achieved using Stille-type cross-coupling reaction of a vinylstannane and a thioester as a key segment assembly process.

    Original languageEnglish
    Pages (from-to)429-445
    Number of pages17
    JournalTetrahedron
    Volume67
    Issue number2
    DOIs
    Publication statusPublished - 2011 Jan 14

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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