An enantiocontrolled entry to the tricyclic core of daphnicyclidin A with five chlral centers Including an all-carbon quaternary center Is reported. The synthesis features a highly dlastereoselectlve conjugate addition of nltromethane, an Ireland- Clalsen rearrangement, and a tandem acyliminium/ Mannich- type reaction.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry