Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on b-alkyl suzuki coupling

Hiroyuki Takakura, Katsuhiko Noguchi, Makoto Sasaki, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Access to polycyclic polyethers is facilitated by a synthetic strategy involving two-step B-alkyl Suzuki coupling reactions for the stereo-selective construction of the polyether skeleton. Thus, a convergent synthetic route to the heptacyclic GHIJKLM ring system 1 of ciguatoxin, a marine algal toxin implicated in ciguatera fish poisoning, was developed. Bn = benzyl.

Original languageEnglish
Pages (from-to)1090-1093
Number of pages4
JournalAngewandte Chemie - International Edition
Volume40
Issue number6
DOIs
Publication statusPublished - 2001 Mar 14
Externally publishedYes

Keywords

  • Ciguatoxin
  • Cross-coupling
  • Natural products
  • Polycycles
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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