Exceptional neurotoxicity is associated with ciguatoxin. The ciguatoxin mimic 1, which contains the F-M framework of the natural product, has been prepared through a convergent synthesis. The two key steps were a Lewis acid mediated intramolecular reaction of a γ-alkoxyallylsilane with an acetal group and an SmI2-mediated intramolecular Reformatsky reaction that permitted construction of the annelated hexahydrooxonin ring system.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 1998|
- Natural products
- Synthetic methods
ASJC Scopus subject areas