Synthetic studies on azadirachtin: Construction of the highly functionalized decalin moiety of azadirachtin

Jun Ishihara, Yuuko Yamamoto, Naoki Kanoh, Akio Murai

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Construction of the left segment of azadirachtin in naturally occurring enantiomer is described. The key reaction is an intramolecular Diels-Alder reaction, which was performed under thermal conditions to afford the highly functionalized decalin compounds selectively.

Original languageEnglish
Pages (from-to)4387-4390
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number23
DOIs
Publication statusPublished - 1999 Jun 4

Keywords

  • Azadirachtin
  • Decalin
  • Diels-Alder reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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