Synthetic Studies on Amphirionin-5: Stereochemical Assignment/Reassignment of the C1-C9 Portion through Stereodivergent Synthesis

Moemi Kanto, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Synthesis of four diastereomers of the C1-C12 fragment of amphirionin-5 has been achieved in a convergent and stereodivergent manner. Detailed comparison of the 1H and 13C NMR data of each compound with those reported for the natural product led to not only the stereochemical assignment of the relative configuration of the C4/C5 stereogenic centers but also reassignment of the proposed relative configuration at C9 of amphirionin-5.

    Original languageEnglish
    Pages (from-to)112-115
    Number of pages4
    JournalOrganic letters
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 2016 Jan 4

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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