Synthetic Studies on Acochlearine: Construction of the A/B/C/E/F Ring System

Kosuke Fujioka, Naoya Miyamoto, Hiroki Toya, Kentaro Okano, Hidetoshi Tokuyama

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6 Citations (Scopus)

Abstract

Synthetic studies on acochlearine are described. The pentacyclic A/B/C/E/F ring system of acochlearine was constructed from a bicyclic enone via chemoselective reductive amination, one-pot bromination-intramolecular Mannich reaction cascade, and 6π-electrocyclization.

Original languageEnglish
Article numberst-2015-u0774-l
Pages (from-to)621-625
Number of pages5
JournalSynlett
Volume27
Issue number4
DOIs
Publication statusPublished - 2016 Mar 1

Keywords

  • C-H functionalization
  • Mannich reaction
  • alkaloids
  • domino reaction
  • halogenation
  • lactams

ASJC Scopus subject areas

  • Organic Chemistry

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    Fujioka, K., Miyamoto, N., Toya, H., Okano, K., & Tokuyama, H. (2016). Synthetic Studies on Acochlearine: Construction of the A/B/C/E/F Ring System. Synlett, 27(4), 621-625. [st-2015-u0774-l]. https://doi.org/10.1055/s-0035-1560384