Synthetic studies on a marine polyether toxin, gambierol: Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

H. Fuwa; M. Sasaki; K. Tachibana

doi:10.1016/S0040-4039(00)01483-0

Synthetic studies on a marine polyether toxin, gambierol: Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

H. Fuwa, M. Sasaki, K. Tachibana

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	8371-8375
Number of pages	5
Journal	Tetrahedron Letters
Volume	41
Issue number	43
DOIs	https://doi.org/10.1016/S0040-4039(00)01483-0
Publication status	Published - 2000 Oct 21

Keywords

Coupling reactions
Polyethers
Suzuki reactions
Toxins

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4039(00)01483-0

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title = "Synthetic studies on a marine polyether toxin, gambierol: Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling",

abstract = "A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.",

keywords = "Coupling reactions, Polyethers, Suzuki reactions, Toxins",

author = "H. Fuwa and M. Sasaki and K. Tachibana",

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language = "English",

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T1 - Synthetic studies on a marine polyether toxin, gambierol

T2 - Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

AU - Fuwa, H.

AU - Sasaki, M.

AU - Tachibana, K.

PY - 2000/10/21

Y1 - 2000/10/21

N2 - A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.

AB - A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.

KW - Coupling reactions

KW - Polyethers

KW - Suzuki reactions

KW - Toxins

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EP - 8375

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 43

ER -

Synthetic studies on a marine polyether toxin, gambierol: Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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