Abstract
A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 8371-8375 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 43 |
DOIs | |
Publication status | Published - 2000 Oct 21 |
Keywords
- Coupling reactions
- Polyethers
- Suzuki reactions
- Toxins
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry