Synthetic studies on a marine polyether toxin, gambierol: Stereoselective synthesis of the FGH ring system via B-alkyl Suzuki coupling

H. Fuwa, M. Sasaki, K. Tachibana

    Research output: Contribution to journalArticlepeer-review

    58 Citations (Scopus)

    Abstract

    A synthetic route to the FGH ring system of gambierol, a marine polyether toxin isolated from the dinoflagellate Gambierdiscus toxicus, has been developed. The present synthesis features B-alkyl Suzuki coupling of the F and H rings, followed by ring-closure of the G ring and stereoselective installation of 1,3-diaxial methyl groups at C21 and C23. (C) 2000 Elsevier Science Ltd.

    Original languageEnglish
    Pages (from-to)8371-8375
    Number of pages5
    JournalTetrahedron Letters
    Volume41
    Issue number43
    DOIs
    Publication statusPublished - 2000 Oct 21

    Keywords

    • Coupling reactions
    • Polyethers
    • Suzuki reactions
    • Toxins

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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