Synthetic studies of enacyloxins: A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito; Wataru Igarashi; Hiroyuki Furukawa; Hiroki Hoshikawa; Teiko Yamada; Shigefumi Kuwahara; Hiromasa Kiyota

Synthetic studies of enacyloxins: A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Hiroki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

Abstract

Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.

Original language	English
Pages (from-to)	645-648
Number of pages	4
Journal	Natural product communications
Volume	10
Issue number	4
Publication status	Published - 2015

Keywords

Antibiotics
Elongation factor Tu
Enacyloxins
Synthetic studies

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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Synthetic studies of enacyloxins : A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments. / Saito, Aki; Igarashi, Wataru; Furukawa, Hiroyuki; Hoshikawa, Hiroki; Yamada, Teiko; Kuwahara, Shigefumi; Kiyota, Hiromasa.

In: Natural product communications, Vol. 10, No. 4, 2015, p. 645-648.

Research output: Contribution to journal › Article › peer-review

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