TY - JOUR
T1 - Synthetic studies of enacyloxins
T2 - A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments
AU - Saito, Aki
AU - Igarashi, Wataru
AU - Furukawa, Hiroyuki
AU - Hoshikawa, Hiroki
AU - Yamada, Teiko
AU - Kuwahara, Shigefumi
AU - Kiyota, Hiromasa
PY - 2015/4
Y1 - 2015/4
N2 - Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.
AB - Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.
KW - Antibiotics
KW - Elongation factor Tu
KW - Enacyloxins
KW - Synthetic studies
UR - http://www.scopus.com/inward/record.url?scp=84933521638&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84933521638&partnerID=8YFLogxK
U2 - 10.1177/1934578x1501000429
DO - 10.1177/1934578x1501000429
M3 - Article
C2 - 25973499
AN - SCOPUS:84933521638
VL - 10
SP - 645
EP - 648
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 4
ER -