Abstract
Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.
Original language | English |
---|---|
Pages (from-to) | 645-648 |
Number of pages | 4 |
Journal | Natural product communications |
Volume | 10 |
Issue number | 4 |
Publication status | Published - 2015 |
Keywords
- Antibiotics
- Elongation factor Tu
- Enacyloxins
- Synthetic studies
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine