Synthetic studies of enacyloxins: A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Hiroki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.

    Original languageEnglish
    Pages (from-to)645-648
    Number of pages4
    JournalNatural product communications
    Volume10
    Issue number4
    DOIs
    Publication statusPublished - 2015 Apr

    Keywords

    • Antibiotics
    • Elongation factor Tu
    • Enacyloxins
    • Synthetic studies

    ASJC Scopus subject areas

    • Pharmacology
    • Plant Science
    • Drug Discovery
    • Complementary and alternative medicine

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