Synthetic studies of cortistatin a analogue from the CD-ring fragment of vitamin D2

Naoyuki Kotoku, Kohei Mizushima, Satoru Tamura, Motomasa Kobayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).

Original languageEnglish
Pages (from-to)1024-1029
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume61
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

Keywords

  • Analogue synthesis
  • Anti-angiogenesis
  • Cortistatin A
  • Marine sponge
  • Vitamin D

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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