Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials

Yoshinosuke Hamada, Hiroshi Egusa, Yoshitoshi Kaneda, Isao Hirata, Naomasa Kawaguchi, Takafumi Hirao, Takuya Matsumoto, Makiko Yao, Kiyoshi Daito, Mayuka Suzuki, Hirofumi Yatani, Michiharu Daito, Masayuki Okazaki, Nariaki Matsuura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3Ap-collagen sponge - as a scaffold biomaterial containing the SVVYGLR motif -were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO3 Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells - as well as prominent angiogenesis - inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalDental materials journal
Volume26
Issue number4
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Bone marrow scaffold biomaterials
  • SVVYGLR

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)

Fingerprint Dive into the research topics of 'Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials'. Together they form a unique fingerprint.

  • Cite this

    Hamada, Y., Egusa, H., Kaneda, Y., Hirata, I., Kawaguchi, N., Hirao, T., Matsumoto, T., Yao, M., Daito, K., Suzuki, M., Yatani, H., Daito, M., Okazaki, M., & Matsuura, N. (2007). Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials. Dental materials journal, 26(4), 487-492. https://doi.org/10.4012/dmj.26.487