Synthetic oligonucleotides as modulators of inflammation

Dennis Klinman, Hidekazu Shirota, Debra Tross, Takashi Sato, Sven Klaschik

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and plasmacytoid dendritic cells, promote the production of Th1 and proinflammatory cytokines, and trigger the maturation/activation of professional APC. CpG ODN are finding use in the treatment of cancer, allergy, and infection. In contrast, ODN containing multiple TTAGGG motifs mimic the immunosuppressive activity of self-DNA, down-regulating the production of proinflammatory and Th1 cytokines. Preclinical studies suggest that "suppressive" ODN may slow or prevent diseases characterized by pathologic immune stimulation, including autoimmunity and septic shock. Extensive studies in animal models suggest that the therapeutic value of CpG and TTAGGG ODN may be optimized by early administration.

Original languageEnglish
Pages (from-to)958-964
Number of pages7
JournalJournal of Leukocyte Biology
Volume84
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1
Externally publishedYes

Keywords

  • Cancer
  • CpG
  • ODN
  • Suppressive
  • Therapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Fingerprint Dive into the research topics of 'Synthetic oligonucleotides as modulators of inflammation'. Together they form a unique fingerprint.

Cite this